Today’s AI technologies have made great advancement in many areas. One area that urgently needs help is the work of first responders, namely, fire fighters, emergency medical services and law enforcement. An AI assistant has been developed to process sensor signals and understand the environment during the critical emergency situations. The AI virtual assistant lives in the emergency vehicle or in the wearable device on the first responder’s body. Deep Neural Networks (DNNs) were trained to be the “eyes” and “ears” of the first responders. The DNNs were trained to understand surrounding video images and audio signals. The AI assistant takes sensory data and provides real-time situational awareness and prioritized action recommendations to the first responders. An AI virtual assistant was trained to help fire fighters to monitor fire and smoke and to predict flashover. An AI assistant helped hazmat team to identify drowning people. Another AI assistant was trained to assist paramedics to respond to emergency calls. The virtual assistant helped search for correct procedures, bridge the communications between the paramedics and the hospital, ensure the correct procedure and best route back to the hospital.